Thymalin 10mg
$ 50.00
Thymalin is a polypeptide isolated from the thymus gland, believed by researchers to help regulate immune functions. Studies have suggested that Thymalin, a naturally occurring polypeptide, is primarily found in the young epidermal cells of the thymus gland. With increasing age, the levels of Thymalin decrease, eventually becoming thinned out and non-uniform in nature. Natural thymic peptides such as Thymalin were first isolated from the thymus gland via a mild acid extraction process. Upon further isolation studies, the proposed immunomodulatory molecule composed by Thymalin (L-Glu-L-Trp) was discovered and researched. This dipeptide molecule in Thymalin may possibly play a role in the peptide mechanism. While both Thymalin and Thymulin are naturally occurring thymic factors, their mode of action is hypothesized by researchers to differ. Thymalin is a polypeptide that may regulate thymic functions at optimal levels, while Thymulin appears to be a zinc-dependent nonapeptide hormone that may possibly enhance the thymic functions in fighting T-cell suppression.
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Storage Instructions:| All of our products are manufactured using the Lyophilization (Freeze Drying) process, which ensures that our products remain 100% stable for shipping for up to 3-4 months. Once the peptides are reconstituted (mixed with bacteriostatic water), they must be stored in the fridge to maintain stability. After reconstitution, the peptides will remain stable for up to 30 days. Lyophilization is a unique dehydration process, also known as cryodesiccation, where the peptides are frozen and then subjected to low pressure. This causes the water in the peptide vial to sublimate directly from solid to gas, leaving behind a stable, crystalline white structure known as lyophilized peptide. The puffy white powder can be stored at room temperature until you're ready to reconstitute it with bacteriostatic water. Once peptides have been received, it is imperative that they are kept cold and away from light. If the peptides will be used immediately, or in the next several days, weeks or months, short-term refrigeration under 4C (39F) is generally acceptable. Lyophilized peptides are usually stable at room temperatures for several weeks or more, so if they will be utilized within weeks or months such storage is typically adequate. However, for longer term storage (several months to years) it is more preferable to store peptides in a freezer at -80C (-112F). When storing peptides for months or even years, freezing is optimal in order to preserve the peptide’s stability. For further information on proper storage techniques, click the link below: Peptide Storage Information
Overview
Studies have been conducted to understand the functioning of both natural and synthetic thymic peptides. The main compounds that have been studied are Thymalin (natural polypeptide), Thymogen (synthetic peptide), and Vilon (its derived dipeptide). The study suggested that all the peptides within this thymic family appear to function via possibly stimulating thymic functions i.e., differentiation of T-cells, induced changes in the nucleotides and cytokine cells and secretion of lymphocytes. The other significant hypothesis made during this study was that the naturally occurring peptide, Thymalin, may potentially stimulate the antioxidant responses, whereas the two synthetic analogues did not appear to alter these responses. Thymalin might contribute indirectly to controlling inflammatory responses, which are typically exacerbated by oxidative damage.
Chemical Makeup
Molecular Formula: C33H54N12O15
Molecular Weight: 858.864 g/mol
Other Known Titles: Thymulin, Thymic Factor
Thymalin and Carcinogenesis
A study involving 76 female rats found that those treated with Thymalin had an extended average lifespan and significantly reduced tumor incidence compared to controls. The peptide may enhance immune mechanisms such as T-cell differentiation and neutrophil activation. Tissue distribution studies also showed rapid absorption of Thymalin, with high concentrations in the liver and lymph nodes, potentially improving immune surveillance and anticancer defenses.
Thymalin and Viral Infection
In a clinical study on HHV-1 patients, Thymalin elevated CD4+ and CD8+ levels and prevented viral reactivation. It reduced immune exhaustion markers PD-1 and PD-L1 while increasing antiviral cytokines IFN-γ and IL-2, suggesting enhanced Th1 immune responses without general immune overactivation.
Thymalin and Toxic Goiter Models
Among 104 subjects with Diffuse Toxic Goiter (DTG), Thymalin—alone or combined with other compounds—helped reduce DTG symptoms and normalized biomarkers of peptide and lipid oxidation.
Thymalin and Lympholeukemia Models
In chronic lymphoid leukemia patients, a combination of Thymalin and plasmapheresis improved physiological function beyond what was seen with chemotherapy alone, suggesting synergistic immunocorrective effects.
Thymalin and Geroprotection
In a long-term aging study with 266 participants, Thymalin—alone or with Epithalamin—improved cardiovascular, neurological, metabolic, and immune function. It potentially supports thymic rejuvenation, lowers systemic inflammation, stabilizes cortisol, and improves glucose and lipid metabolism.
Disclaimer
All products offered by 1stPharma.com are intended strictly for laboratory and scientific research purposes only. These products are not approved by the FDA, are not medicines or supplements, and are not sold for human consumption, medical treatment, or veterinary use. Any discussion of potential benefits is based solely on preclinical findings.
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