Semax 10mg
$ 50.00
Semax is a laboratory-synthesized derivative of adrenocorticotropic hormone (ACTH). Studies indicate that it can elevate levels of brain-derived neurotrophic factor (BDNF), supporting neuroprotection and immune modulation. Research also suggests potential roles in enhancing cardiovascular health, regulating pain perception, and influencing blood clotting mechanisms.
All of our products are manufactured using the Lyophilization (Freeze Drying) process, which ensures that our products remain 100% stable for shipping for up to 3-4 months. Once the peptides are reconstituted (mixed with bacteriostatic water), they must be stored in the fridge to maintain stability. After reconstitution, the peptides will remain stable for up to 30 days. Lyophilization is a unique dehydration process, also known as cryodesiccation, where the peptides are frozen and then subjected to low pressure. This causes the water in the peptide vial to sublimate directly from solid to gas, leaving behind a stable, crystalline white structure known as lyophilized peptide. The puffy white powder can be stored at room temperature until you're ready to reconstitute it with bacteriostatic water. Once peptides have been received, it is imperative that they are kept cold and away from light. If the peptides will be used immediately, or in the next several days, weeks or months, short-term refrigeration under 4C (39F) is generally acceptable. Lyophilized peptides are usually stable at room temperatures for several weeks or more, so if they will be utilized within weeks or months such storage is typically adequate. However, for longer term storage (several months to years) it is more preferable to store peptides in a freezer at -80C (-112F). When storing peptides for months or even years, freezing is optimal in order to preserve the peptide’s stability. For further information on proper storage techniques, click the link below: Peptide Storage Information
Semax Overview
Semax, originally developed in Russia, has been extensively studied for its potential in supporting neurological and cognitive health. Research suggests benefits in stroke recovery, cognitive decline, dementia, and optic nerve inflammation. It has also demonstrated antidepressant and anxiolytic properties, as well as potential immune-modulating effects. Findings indicate that Semax increases brain-derived neurotrophic factor (BDNF) levels in the central nervous system, along with serotonin and dopamine, which may contribute to its neuroprotective and mood-regulating effects.
Semax Structure
Sequence: Met-Glu-His-Phe-Pro-Gly-Pro
Molecular Formula: C37H51N9O10S
Molecular Weight: 813.92 g/mol
CAS Number: 80714-61-0
Synonyms: Pro-Gly-Pro-ACTH
Source: PubChem
What Is Semax?
Semax is a synthetic analogue of adrenocorticotropic hormone (ACTH), derived from amino acids 4–10 of the ACTH fragment. Its unique structure enables activity in the central nervous system, where it has been linked to enhanced gene expression, neuroplasticity, and modulation of neurotransmitter systems.
Semax and Brain Function
Functional MRI studies reveal that Semax activates the brain’s default mode network, a system associated with environmental monitoring, attention, and social cognition. This may enhance resting attentiveness and cognitive flexibility, potentially improving problem-solving, memory, and creativity.
Semax in Stroke and Neuroprotection
Preclinical and clinical studies suggest that Semax stimulates gene expression tied to vascular function, blood cell formation, and neuroprotection. In stroke models, it promotes neuronal survival, stabilizes mitochondrial function, and supports nutrient delivery to brain tissue. Clinical use in rehabilitation has been associated with accelerated recovery, higher motor function, and increased plasma BDNF levels.
Gene Expression and Learning
Research in animal models indicates that Semax rapidly influences gene expression in both the hippocampus and frontal cortex—key regions for learning, memory, and executive function. These effects are linked to elevated NGF and BDNF levels, supporting theories that Semax may enhance neuroplasticity and improve learning efficiency.
Cognitive and Emotional Effects
Studies suggest that ACTH and its analogues, including Semax, protect learning and memory in models of epilepsy and may serve as nootropic agents. Additional research highlights antidepressant potential, with BDNF stimulation considered a key factor in regulating brain function during depression. This mechanism may complement traditional SSRIs by accelerating neurogenesis and mood stabilization.
Safety and Use
In preclinical models, Semax shows good bioavailability, low toxicity, and minimal side effects. However, human clinical data remain limited. At 1stPharma.com, Semax is provided exclusively for laboratory and scientific research purposes.
Disclaimer
All products offered by 1stPharma.com are intended strictly for laboratory and scientific research purposes only. These products are not approved by the FDA, are not medicines or supplements, and are not sold for human consumption, medical treatment, or veterinary use. Any discussion of potential benefits is based solely on preclinical findings.
Referenced Citations
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Lebedeva IS et al., Bull. Exp. Biol. Med., 2018.
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Mars RB et al., Front. Hum. Neurosci., 2012.
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Medvedeva EV et al., BMC Genomics, 2014.
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Gusev EI et al., Zh. Nevrol. Psikhiatr., 2018.
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Agapova TI et al., Mol. Genet. Mikrobiol. Virusol., 2008.
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Scantlebury MH et al., Neurosci. Lett., 2017.
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Deltheil T et al., Neuropharmacology, 2008.
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Ivanov A et al., Bull. Exp. Biol. Med., 2017.
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Bobyntsev II et al., ResearchGate, 2015.
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10mg |
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