Selank 10mg
$ 50.00
Selank is a synthetic heptapeptide derived from the naturally occurring peptide Tuftsin, a fragment of immunoglobulin G (IgG) involved in immune regulation. Selank combines Tuftsin at the N-terminus with a Pro-Gly-Pro (PGP) tripeptide at the C-terminal end. The PGP sequence may enhance Selank’s ability to cross the blood-brain barrier (BBB) through altered hydrophobicity and potential receptor-mediated transport mechanisms. These structural features underpin its exploration in neuroregulation, immune modulation, and metabolic research contexts.
All of our peptides are produced using the lyophilization (freeze-drying) process, which ensures that products remain stable for shipping for up to 3–4 months. Once reconstituted with bacteriostatic water, peptides must be stored in a refrigerator to maintain integrity, where they will remain stable for up to 30 days. Lyophilization, also known as cryodesiccation, is a specialized dehydration method in which peptides are frozen and then exposed to low pressure. This process allows water to sublimate directly from solid to gas, leaving behind a stable, crystalline white powder. This lyophilized form can be safely stored at room temperature until reconstitution. Upon receipt, peptides should be kept cold and protected from light. For short-term use—spanning several days to weeks—refrigeration at or below 4°C (39°F) is generally sufficient. Lyophilized peptides also maintain stability at room temperature for extended periods, making short-term storage convenient and effective. For long-term storage over several months or longer, peptides are best preserved in a freezer at –80°C (–112°F). Freezing in these conditions ensures that peptide stability and activity are maintained over time. For extended preservation, particularly for storage spanning multiple months to years, peptides are best kept in ultra-low freezers at approximately –80°C (–112°F). Under these long-term conditions, structural stability is maximized, ensuring peptides retain their quality and suitability for future research applications.
Selank Overview
Selank is a synthetic peptide originally developed in Russia and recognized for its nootropic and anxiolytic properties. It is a structural analogue of tuftsin, a naturally occurring immunomodulatory peptide, but includes four additional amino acids to improve metabolic stability and extend biological half-life. Like tuftsin, Selank influences immune system activity, neurotransmitter balance, and brain-derived neurotrophic factor (BDNF).
Clinical studies have explored Selank as a potential therapy for generalized anxiety disorder (GAD), showing promising outcomes without the dependency risks associated with traditional anxiolytics.
Selank Structure
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Sequence: Thr-Lys-Pro-Arg-Pro-Gly-Pro
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Molecular Formula: C33H57N11O9
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Molecular Weight: 751.87 g/mol
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CAS Number: 129954-34-3
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Synonyms: Selanc
Selank Research
Anxiety and GABA-Related Gene Modulation
Selank exerts strong anti-anxiety and neuroprotective effects by modulating the GABAergic system. Research from the Institute of Molecular Genetics in Russia indicates that Selank alters the expression of over 50 genes related to GABA signaling, directly influencing receptor affinity for GABA.
Like benzodiazepines, Selank enhances calming neurotransmission through the GABA receptor but differs in its safety profile — it is non-addictive, does not cause withdrawal, and lacks amnesic effects. Studies also show synergy between Selank and benzodiazepines in managing chronic mild stress models.
Selank and Enkephalin Preservation
Patients with anxiety disorders often display elevated enkephalinase activity, leading to shortened half-lives of enkephalins, the body’s natural stress- and pain-regulating peptides. Selank inhibits this enzyme activity, prolonging enkephalin function and restoring the body’s natural anxiolytic balance. This mechanism may explain Selank’s dual role in reducing both anxiety and pain perception.
Immunomodulatory Effects
Selank has demonstrated the ability to suppress IL-6 expression in individuals with depression, but not in healthy controls — suggesting disease-specific immunomodulation. Further studies in rodents reveal that Selank regulates over 30 genes tied to immune function, including cytokines, chemokines, and their receptors.
This activity suggests potential in treating anxiety-asthenic disorders, where immune dysfunction contributes to symptoms such as fatigue, headaches, palpitations, and nerve pain.
Cognitive Enhancement and Memory
Anxiety often interferes with learning and memory, but Selank’s effects go beyond simply reducing stress. Research indicates that Selank improves memory trace stability, enhances hippocampal gene expression, and modulates proteins tied to synaptic plasticity.
Animal studies demonstrate improved learning capacity and memory retention, even in models of neurotoxin-induced brain damage. These findings suggest potential for Selank in neurorehabilitation and cognitive performance enhancement.
Pain Modulation
Through its role in enkephalin preservation, Selank indirectly influences the opioid receptor system, providing a natural means of pain modulation while also blunting stress responses. This positions Selank as a unique candidate for research into stress-linked chronic pain.
Research Summary
Selank represents a multi-functional neuropeptide with anxiolytic, nootropic, immunomodulatory, and analgesic potential. Unlike traditional anxiolytics, Selank offers a favorable safety profile, lacking sedative dependency or withdrawal effects. While preclinical and clinical studies show strong promise, ongoing research is needed to fully establish its mechanisms and therapeutic applications.
Disclaimer
All Selank offered by 1stPharma.com is intended strictly for in-vitro research use only. These products are not approved for human or veterinary use. They are not intended to diagnose, treat, cure, or prevent any disease.
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10mg |
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