PINEALON 20mg
$ 65.00
Pinealon is an investigational tripeptide comprising three amino acids. Preclinical studies report modulation of behavior and broad cytoprotection under hypoxic stress across multiple cell types. It has been actively explored for effects on circadian regulation, memory consolidation, and learning performance. Additional research indicates putative geroprotective activity, most notably within the central nervous system, with preliminary evidence suggesting potential relevance to neurocognitive disorders—including Alzheimer’s disease—though any therapeutic use remains unproven.
All 1stPharma research peptides are produced through the lyophilization (freeze-drying) process, which is designed to maintain molecular stability during transport for approximately three to four months. Following reconstitution with bacteriostatic water, peptide solutions must be stored under refrigeration to preserve their structure. Under these conditions, the compounds typically remain stable for up to 30 days. However peptides have a shelf life of up to 2 years when refrigerated. Lyophilization—sometimes referred to as cryodesiccation—is a specialized dehydration technique in which peptides are frozen and then exposed to reduced pressure. This process allows water molecules to sublimate directly from ice to vapor, leaving behind a stable, crystalline material often observed as a fine white powder. In this form, peptides may be kept at ambient temperature until reconstitution with bacteriostatic water is required. After receipt, peptides should be protected from light exposure and stored in a cool environment. For short-term use, refrigeration at or below 4°C (39°F) is generally appropriate, providing adequate stability for several days to weeks. While lyophilized peptides are often resilient at room temperature for limited periods, refrigerated storage is recommended whenever possible to ensure optimal integrity. For extended preservation, particularly for storage spanning multiple months to years, peptides are best kept in ultra-low freezers at approximately –80°C (–112°F). Under these long-term conditions, structural stability is maximized, ensuring peptides retain their quality and suitability for future research applications.
What is Pinealon?
Pinealon is a short, synthetic tripeptide composed of three amino acids: glutamic acid, aspartic acid, and arginine. Classified among peptide bioregulators, it is notable for its ability to influence gene expression directly at the DNA level. Unlike many peptides that act through receptor binding, Pinealon has been observed to penetrate both cellular and nuclear membranes, allowing for interaction with genetic material. This unique mechanism is the basis for its wide range of biological effects reported in experimental models, including cellular protection against hypoxia and oxidative stress, modulation of circadian rhythms, and potential cognitive benefits such as improvements in memory and learning capacity. Researchers have also explored its possible applications in aging studies, where it has been associated with neuroprotection and regulation of metabolic activity through the pineal gland.
Pinealon Highlights
- Tripeptide regulator (Glu–Asp–Arg) with DNA-level interaction potential
- Studied for protective effects against hypoxia and oxidative stress
- Linked to regulation of circadian rhythms and sleep–wake cycle balance
- Investigated for modulation of serotonin synthesis via epigenetic pathways
- Explored in connection with irisin expression, telomere maintenance, and aging processes
- Evaluated for roles in neuroprotection, cardiovascular stress models, and regenerative research
Pinealon Peptide Structure
Sequence: Glu–Asp–Arg
Molecular Formula: C15H26N6O8
Molecular Weight: 418.41 g/mol
PubChem CID: 18220191
Synonyms: Glutamylaspartylarginine, T-33 Peptide
Pinealon Skeletal Structure — 1stPharma
Research Areas
Aging and Longevity
Evidence from laboratory studies indicates that Pinealon may have protective effects against age-related decline in the central nervous system. Russian research suggests that Pinealon and related short peptides may help regulate biological markers of aging, potentially slowing degenerative processes. Its impact on muscle cells, specifically through modulation of irisin expression, has also drawn attention. Irisin plays an important role in telomere maintenance, metabolic efficiency, and cellular resilience, making Pinealon’s influence in this pathway particularly relevant to aging research and systemic vitality.
Neuroprotection
Preclinical models show that Pinealon protects neurons from oxidative injury and hypoxic stress by reducing reactive oxygen species and enhancing intrinsic antioxidant systems. It has also been linked to mitigating NMDA receptor–mediated excitotoxicity, a process implicated in alcohol withdrawal, ischemic stroke, and traumatic brain injury. Through these mechanisms, Pinealon demonstrates potential neuroprotective properties that warrant further exploration in the context of cognitive decline and neurodegenerative conditions.
Gene Expression and Epigenetics
Unlike most peptides that rely on surface receptor pathways, Pinealon penetrates the nuclear membrane and directly engages with DNA. In vitro studies suggest that this interaction enables modulation of the cell cycle and activation of survival mechanisms under oxidative stress. By influencing transcriptional regulation, Pinealon may alter cellular resilience, proliferation, and repair processes, positioning it as a unique subject in epigenetic and genetic regulation research.
Mood and Serotonin Regulation
Laboratory investigations have identified Pinealon’s ability to enhance expression of tryptophan hydroxylase, the rate-limiting enzyme in serotonin biosynthesis. Since serotonin plays essential roles in cognition, mood stabilization, and neuroprotection, Pinealon’s effect on this pathway raises interest for its potential role in mood regulation and depression research. Unlike selective serotonin reuptake inhibitors (SSRIs), which carry significant side effect profiles, modulation via natural peptide regulators may offer a physiological alternative that minimizes adverse outcomes.
Cardiac and Tissue Protection
Pinealon has been studied in ischemic models, including stroke and myocardial infarction, where it demonstrated the ability to suppress caspase-3 activity, a key mediator of apoptosis. By reducing programmed cell death, Pinealon has shown protective potential in both neural and cardiac tissues. Additional studies in skin cells revealed that Pinealon may encourage cell proliferation and support regeneration, suggesting applications in wound healing, dermal repair, and tissue preservation across organ systems.
Sleep and Circadian Rhythm
Research into Pinealon’s action on the pineal gland highlights its potential role in regulating disrupted circadian rhythms. Experimental results suggest benefits in restoring normal sleep cycles affected by shift work, long-distance travel, or stress-related disruptions. Improved circadian balance may extend benefits to cognition, cardiovascular health, mood stability, and recovery processes. Given the strong correlation between sleep quality and systemic aging, Pinealon’s ability to influence circadian regulation remains a critical area of investigation.
Future Research
Future directions in Pinealon research focus on clarifying its unique DNA-level activity and its implications across multiple organ systems. Areas of interest include potential applications in neurodegeneration, cardiovascular stress recovery, regenerative medicine, and anti-aging interventions. While still in early stages, Pinealon’s distinctive mechanism and promising preclinical data position it as a valuable candidate for continued study in peptide bioregulation.
Disclaimer
All Pinealon products provided by 1stPharma are exclusively intended for in-vitro research purposes only. This compound is not a pharmaceutical drug, dietary supplement, or therapeutic agent. It has not been evaluated or approved by the FDA or any other regulatory body for human or veterinary use. Administration to humans or animals is strictly prohibited. For further details, please visit 1stPharma.com.
Referenced Citations
- Fedoreyeva, L. I., Kireev, I. I., Khavinson, V. K., & Vanyushin, B. F. (2011). Penetration of short peptides into nuclei and DNA interactions. Biochemistry (Moscow), 76(11), 1210–1219.
- Meshchaninov, V. N., Tkachenko, E. L., Zharkov, S. V., et al. (2015). Effects of synthetic peptides on biological aging in CNS syndromes. Advances in Gerontology, 28(1), 62–67.
- Khavinson, V. K., Kuznik, B. I., Tarnovskaya, S. I., & Lin’kova, N. S. (2016). Peptides and irisin regulation in telomere biology. Bulletin of Experimental Biology and Medicine, 160(3), 347–349.
- Rana, K. S., et al. (2014). Plasma irisin levels and telomere length. Age, 36(2), 995–1001.
- Arutjunyan, A., et al. (2012). Pinealon neuroprotection in prenatal models. International Journal of Clinical and Experimental Medicine, 5(2), 179–185.
- Khavinson, V., et al. (2011). Pinealon and oxidative stress suppression. Rejuvenation Research, 14(5), 535–541.
- Kozina, L. S. (2008). Antihypoxic properties of short peptides. Advances in Gerontology, 21(1), 61–67.
- Zhang, J., & Zhang, W. (2016). Irisin as a link between exercise and brain function. Biomolecular Concepts, 7(4), 253–258.
- Khavinson, V. K., Lin’kova, N. S., et al. (2014). Short peptides and serotonin expression. Bulletin of Experimental Biology and Medicine, 157(1), 77–80.
- MendzheritskiÄ, A. M., et al. (2014). Cytokine regulation and caspase-3 modulation by Pinealon. Advances in Gerontology, 27(1), 94–97.
- JACC (2011). Caspase-3 elevation in myocardial infarction. Journal of the American College of Cardiology, 57(2), 220.
- Voicekhovskaya, M. A., et al. (2012). Bioregulatory peptides in skin cell cultures. Bulletin of Experimental Biology and Medicine, 152(3), 357–359.
- Bashkireva, A. S., & Artamonova, V. G. (2012). Peptide correction of circadian disorders. Advances in Gerontology, 25(4), 718–728.
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