Oxytocin 2mg
$ 30.00
Oxytocin is a naturally occurring cyclic peptide hormone composed of nine amino acids, secreted by the pituitary gland and acting as a neurotransmitter in the brain. It is created by the hypothalamus, stored in the posterior pituitary, and released in response to physiological stimuli. Unlike many hormones, oxytocin works through a positive feedback mechanism, where initial secretion triggers further release. It binds to G-protein coupled receptors, increasing intracellular calcium, which drives uterine contractions during labor and stimulates milk ejection during lactation.
At 1stPharma, all peptides are processed using lyophilization (freeze-drying) to ensure maximum stability during shipping, allowing products to remain preserved for approximately 3–4 months under normal conditions. Once reconstituted with bacteriostatic water, peptides must be kept refrigerated to maintain integrity and remain viable for up to 30 days. Lyophilization, also known as cryodesiccation, is a specialized dehydration process where peptides are first frozen and then exposed to low pressure. This causes water to sublimate directly from solid to vapor, leaving behind a stable, crystalline white peptide powder. In this form, the compound can be stored at room temperature until it is reconstituted. Upon receipt, peptides should always be kept cool and protected from light. For short-term use (within days, weeks, or a few months), refrigeration at approximately 4°C (39°F) is sufficient. Lyophilized peptides are generally stable for several weeks at room temperature, making them suitable for near-term use without significant degradation. For long-term preservation (spanning several months to years), peptides are best stored in a deep freezer at -80°C (-112°F). Freezing ensures optimal stability and helps protect the peptide’s structure and activity over extended periods. For additional guidance on handling and storage best practices, please see: Peptide Storage Information. For extended preservation, particularly for storage spanning multiple months to years, peptides are best kept in ultra-low freezers at approximately –80°C (–112°F). Under these long-term conditions, structural stability is maximized, ensuring peptides retain their quality and suitability for future research applications.
Overview
Mechanism: Oxytocin acts through G-protein coupled receptors to raise intracellular calcium levels, driving smooth muscle contractions in the uterus and mammary glands. Study Insights: Both natural and synthetic forms (recombinant oxytocin) act via this mechanism, amplifying release through positive feedback loops during labor and lactation. Key Findings: Oxytocin plays a central role in parturition, milk let-down, and feedback-driven hormonal signaling.
Chemical Makeup
Molecular Formula: C43H66N12O12S2 Molecular Weight: 1007.193 g/mol Other Names:
Endopituitrina
Dopamine Signaling
Mechanism: Oxytocin interacts with dopaminergic pathways in brain regions like the ventral tegmental area (VTA) and nucleus accumbens, influencing reward and sexual behavior. Study Insights: It may enhance dopamine release or receptor sensitivity, boosting motivation and reward perception related to social and sexual behaviors. Key Findings: Oxytocin modulates dopamine and nitric oxide signaling, shaping anticipatory and reward-related behaviors.
Neuroplasticity
Mechanism: Through G-protein coupled receptor activation, oxytocin elevates intracellular calcium, affecting neuronal excitability and synaptic modulation. Study Insights: Receptor distribution across neural and glial cells suggests a broad role in regulating neurotransmission, synaptic plasticity, and neurogenesis. Key Findings: Oxytocin can modulate the balance between excitatory and inhibitory neurotransmission, potentially shaping neural circuit development and function.
Labor Induction
Mechanism: Oxytocin increases uterine contractility through calcium signaling and positive feedback. Study Insights: A randomized clinical trial (n=252) compared continuous vs. discontinued oxytocin administration after active labor onset. Cesarean rates were 32 in the continuous group vs. 24 in the discontinued group, with similar infant outcomes. Key Findings: Oxytocin administration strategies may influence delivery outcomes, highlighting its critical role in labor dynamics.
Lactation
Mechanism: Oxytocin triggers contraction of myoepithelial cells in mammary glands, leading to milk ejection. Study Insights: A retrospective study (n=200) found early breastfeeding difficulties were more common in oxytocin-exposed mothers (27% vs. 14%), potentially influenced by pre-gestational BMI. Over time, breastfeeding rates improved significantly. Key Findings: Oxytocin affects early lactation dynamics, with potential modulation by maternal factors.
Vasodilation
Mechanism: Oxytocin may cause dilation of peripheral blood vessels, influencing cardiac tone. Study Insights: In pregnant women during the first trimester, oxytocin was associated with vasodilation of small arteries and increased left ventricular ejection time. Key Findings: Oxytocin may exert vasodilatory effects relevant to cardiovascular adaptation in pregnancy.
Autism
Mechanism: Oxytocin is involved in social and communicative brain functions. Lower oxytocin levels have been observed in autistic individuals. Study Insights: A clinical study (n=59) found lower plasma oxytocin in autistic boys vs. controls. Elevating oxytocin improved VABS behavioral scores. Key Findings: Oxytocin supplementation may positively influence social behavior in autism models.
Disclaimer
All products offered by 1stPharma.com are intended strictly for laboratory and scientific research purposes only. These products are not approved by the FDA, are not medicines or supplements, and are not sold for human consumption, medical treatment, or veterinary use. Any discussion of potential benefits is based solely on preclinical findings.
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2mg |
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