Melanotan2 10mg
$ 60.00
Melanotan 2 is a synthetic analog of the α -melanocyte-stimulating hormone (α -MSH). It is a cyclic heptapeptide that demonstrates modified receptor affinity compared to its natural counterpart. In addition to potentially stimulating melanogenesis (the production of melanin pigment) in dermal cells, it has been studied for interactions with receptors linked to appetite and arousal regulation.
All peptides offered by 1stPharma are produced through the lyophilization (freeze-drying) process, a method that preserves molecular stability during handling and transport for approximately 3–4 months. Once reconstituted with bacteriostatic water, the solution must be stored under refrigeration to maintain integrity, where it generally remains viable for up to 30 days. Lyophilization, also referred to as cryodesiccation, is a specialized dehydration technique in which the compound is frozen and then placed under reduced pressure. This causes the frozen water content to sublimate directly from solid ice to vapor, leaving behind a stable, crystalline peptide powder. The resulting white, porous material can be kept at room temperature until reconstitution is required. After delivery, peptides should be safeguarded from light exposure and stored in a cool environment. For short-term use spanning several days to weeks, refrigeration at or below 4°C (39°F) is recommended. While lyophilized peptides may remain structurally intact at room temperature for weeks, cold storage provides added assurance of stability for ongoing research. For extended preservation lasting months or years, ultra-low freezing is preferred. Storage at –80°C (–112°F) offers the most reliable option for maintaining peptide quality and consistency over long durations. For detailed guidance on peptide handling and storage protocols, please refer to: Peptide Storage Information – 1stPharma.com For extended preservation, particularly for storage spanning multiple months to years, peptides are best kept in ultra-low freezers at approximately –80°C (–112°F). Under these long-term conditions, structural stability is maximized, ensuring peptides retain their quality and suitability for future research applications.
Overview
Melanotan 2 is considered a non-selective agonist capable of binding to four melanocortin receptor subtypes (MC1 R, MC3 R, MC4 R, and MC5 R). Each receptor subtype is associated with different physiological roles: • MC1 R ‒ Found in melanocytes, associated with pigmentation and melanin production. • MC3 R ‒ Present in the brain and placenta, thought to be involved in appetite modulation. • MC4 R ‒ L ocated in the central nervous system, possibly involved in arousal and sexual behavior. • MC5 R ‒ Distributed across multiple tissues, though its exact role remains unclear. For example, MC1 R activation by Melanotan 2 may stimulate eumelanin production, resulting in darker pigmentation of the epidermal layer. Binding with MC4 R may activate supraspinal centers linked to increased libido, with signals transmitted to sympathetic and parasympathetic centers in the spinal cord.
Chemical Makeup
- Other Known Titles: MT-II
- Molecular Weight: 1 0 2 4 .1 9 g/mol
- Molecular Formula: C5 0 H6 9 N1 5 O9
Research and Clinical Studies
In murine models of induced peripheral nerve injury, Melanotan 2 exposure was associated with sensory recovery within 4 8 hours. When combined with chemotherapeutic agents, it appeared to offer partial neuroprotection against neurotoxicity. This action is believed to be mediated by MC4 receptors, potentially supporting neurite outgrowth and nerve regeneration.
Clinical studies suggest Melanotan 2 may increase arousal signaling in over 8 0 % of subjects, compared to 2 0 % for placebo. This effect is hypothesized to involve MC4 receptor activation and downstream dopaminergic and oxytocinergic pathways within the hypothalamus.
Melanotan 2 has been hypothesized to influence neurodevelopmental signaling by stimulating oxytocin release in MC4 R-sensitive circuits. This may recalibrate neurotransmitter dynamics involving serotonin, glutamate, dopamine, and GABA̶ potentially impacting social cognition and synaptic plasticity.
By engaging MC1 R on melanocytes, Melanotan 2 may increase eumelanin synthesis and darken skin without UV exposure. Its cyclic structure supports prolonged receptor activity, which has led to research into controlled sunless tanning models in experimental settings.
Disclaimer
All products offered by 1stPharma.com are intended strictly for laboratory and scientific research purposes only. These products are not approved by the FDA, are not medicines or supplements, and are not sold for human consumption, medical treatment, or veterinary use. Any discussion of potential benefits is based solely on preclinical findings.
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10mg |
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