Glutathione 1500mg
$ 80.00
Glutathione is a powerful antioxidant and key regulator of numerous biochemical pathways within the body. While naturally abundant in human tissues, its levels decline with age, contributing to cellular stress and degeneration. Scientific research indicates that glutathione may help protect against neurodegenerative disorders, support cartilage and joint health, slow age-related changes in the eyes, strengthen immune function, and enhance skin vitality. Collectively, these findings highlight glutathione as a vital anti-aging molecule with wide-ranging benefits for cellular protection and overall health.
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All peptides from 1stPharma.com are produced through the lyophilization (freeze-drying) process, which ensures complete stability for shipping and handling for up to 3–4 months. After reconstitution with bacteriostatic water, peptides should always be stored in a refrigerator to maintain their integrity, where they typically remain stable for up to 30 days. Lyophilization, also known as cryodesiccation, is a specialized preservation method in which peptides are frozen and placed under reduced pressure. This allows water to sublimate directly from ice to vapor, leaving behind a solid, stable white powder. The resulting lyophilized peptide can be safely stored at room temperature until it is ready for reconstitution. Upon receipt, peptides should be kept in a cool, dark environment to avoid degradation. For short-term use (days to weeks), refrigeration at or below 4°C (39°F) is generally sufficient. In many cases, lyophilized peptides remain stable at room temperature for several weeks, making this acceptable when used in the near term. For long-term preservation (spanning several months to years), storage in an ultra-low freezer at –80°C (–112°F) is strongly recommended. This ensures maximum stability, helping preserve peptide structure and quality for future research applications. For additional details on best practices for storage and handling, please refer to: Peptide Storage Information. For extended preservation, particularly for storage spanning multiple months to years, peptides are best kept in ultra-low freezers at approximately –80°C (–112°F). Under these long-term conditions, structural stability is maximized, ensuring peptides retain their quality and suitability for future research applications.
L-Glutathione Overview
L-Glutathione is a tripeptide composed of cysteine, glutamic acid, and glycine. Naturally present in nearly all living cells, it serves as a central antioxidant and cellular regulator. Within human physiology, it plays a critical role in hepatic detoxification, mitochondrial protection, and redox homeostasis in the central nervous system. Glutathione is especially vital in safeguarding neurons and maintaining hepatic integrity. Diminished glutathione levels have been strongly correlated with oxidative stress–related disorders such as Parkinson’s disease, cataracts, and diabetic retinopathy. Research suggests that this decline occurs both as a byproduct and an accelerator of aging, further compounded by chronic illness and metabolic dysfunction.
While dietary intake and oral supplementation are common, the bioavailability of glutathione through the gastrointestinal tract remains limited due to enzymatic degradation. Alternative delivery routes, including parenteral or intranasal administration, have demonstrated markedly superior systemic absorption and efficacy in clinical studies. Moreover, age-associated declines in glutathione synthesis—often emerging around midlife—cannot be fully offset by precursor supplementation such as N-acetyl-L-cysteine (NAC), reinforcing the importance of direct replenishment.
L-Glutathione Molecular Characteristics
Molecular Formula: C₁₀H₁₇N₃O₆S
Molecular Weight: 307.33 g/mol
PubChem CID: 124886
CAS Number: 70-18-8
Alternative Names: GSH, Glutathione, Isethion
Antioxidant Function and Redox Regulation
L-Glutathione functions as the body’s master antioxidant, providing a critical defense against reactive oxygen species (ROS) and free radicals. The sulfhydryl group in its cysteine residue enables direct neutralization of peroxides, hypochlorous acid, and nitrogen-based radicals. This redox activity not only protects cellular DNA, proteins, and membranes but also sustains the antioxidant cycles of vitamins C and E. Glutathione exists both intracellularly and extracellularly, with the highest concentrations found in hepatic, neural, and pulmonary tissues. Adequate levels are essential for cellular resilience, immune competence, and detoxification efficiency.
Clinical studies link reduced glutathione concentrations with numerous pathological conditions, including diabetes, HIV infection, and certain cancers. Consequently, glutathione quantification is being explored as a diagnostic biomarker for oxidative burden, disease progression, and therapeutic response.
Biological and Metabolic Roles
Beyond antioxidation, L-Glutathione participates in critical biochemical pathways such as leukotriene and prostaglandin synthesis—key mediators of inflammation and immune regulation. It acts as a cofactor in enzymatic reactions, modulating nitric oxide pathways and supporting cardiovascular stability. Within the endoplasmic reticulum, glutathione assists in proper protein folding and disulfide bond formation, processes essential for receptor functionality and cellular signaling fidelity.
Emerging research suggests that glutathione also influences neurotransmission by modulating redox balance at NMDA and purinergic receptors. This regulatory role underscores its importance in maintaining neuronal communication and protecting against excitotoxic injury.
Glutathione, Aging, and Oxidative Stress
With advancing age, endogenous synthesis of glutathione declines significantly, contributing to oxidative imbalance, mitochondrial impairment, and accelerated cellular aging. Studies show that replenishment through injectable or inhaled formulations may restore redox equilibrium, enhance cellular repair, and mitigate visible and systemic effects of aging. By preserving DNA integrity and enzymatic function, glutathione helps slow age-related degeneration in tissues such as the brain, skin, and eyes.
Glutathione and the Central Nervous System
Research highlights the importance of glutathione in neuroprotection. Deficiency in neuronal glutathione accelerates ferroptosis—an iron-dependent form of programmed cell death implicated in neurodegenerative disorders such as Parkinson’s and Alzheimer’s disease. Restoring glutathione levels has been shown to enhance neuronal resilience and reduce oxidative injury following ischemic or metabolic stress. Because synthesis capacity diminishes with age, supplementation via injectable or nasal routes is considered the most effective method for increasing central nervous system concentrations.
Ophthalmic and Dermatologic Benefits
Within ocular tissue, glutathione supports lens transparency and retinal metabolism by maintaining proteins in their reduced state and preventing oxidative crosslinking. Low glutathione concentrations in the lens are closely associated with cataract formation and degenerative retinal changes. Experimental data also demonstrate that topical or systemic glutathione administration may preserve visual acuity and protect against photo-oxidative damage.
Dermatological studies indicate that glutathione contributes to improved skin tone, reduced pigmentation, and enhanced elasticity. Through modulation of melanin synthesis and antioxidant protection, it promotes a more youthful and even complexion while reducing photoaging and free radical-induced damage.
Glutathione in Immunological Health
The immune system relies heavily on glutathione for optimal cellular defense. While supplementation has minimal impact in healthy individuals, it exerts profound effects under oxidative or infectious stress. Research demonstrates that elevating glutathione levels enhances lymphocyte proliferation, increases natural killer cell activity, and supports overall immune responsiveness—particularly in immunocompromised conditions such as HIV infection.
Research and Clinical Insights
Investigators continue to explore glutathione’s diverse physiological roles, from cancer prevention to cognitive health. Although oral formulations have limited absorption, ongoing development of liposomal and transdermal delivery systems shows promise for improving systemic uptake. Among leading experts in the field, Dr. Nayan Patel’s work on transdermal glutathione delivery has advanced understanding of effective antioxidant supplementation strategies.
1st Pharma Research Use Policy
L-Glutathione exhibits minimal adverse effects, with demonstrated subcutaneous and intranasal bioavailability in preclinical models. All 1st Pharma peptide products, including L-Glutathione, are strictly intended for in-vitro laboratory and scientific research purposes only. They are not approved for human or animal use, diagnosis, or therapy.
All data and information presented are for educational and investigational reference only.
| Packing | 1500mg |
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